Sildenafil (generic Viagra)
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DESCRIPTION
Sildenafil was created by a group of pharmaceutical scientists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in high blood pressure and angina. The first clinical tests were conducted in Morriston Hospital in Swansea.The first clinical tests showed that the drug had little effect on angina, but that it could induce penile erections.So it was decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996 and. It became the first drug approved for use in erectile dysfunction in the US. In 1999 it appeared in sale.
Even though sildenafil is available only by prescription, it was advertised openy to consumers on in U.S even through such famous people as former United States Senator Bpenileob Dole and Pele(the soccer star). Presently the drug can be freely purchased on the internet only after an online consultation.
Vaigra (generic Sildenafil) has become so popular, that the producers of other potency raising medecines call their preparates "Viagra", sometimes faking the shape and color of the original tablets. In 2007 some restictions were imposed concerning free sale of Viagra without doctor consultation and prescribtion.
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Sildenafil
Sildenafil 25 mg
 
Sildenafil 50 mg
 
Sildenafil 100 mg
 

Aphrodisiac
Sildenafil is commonly and increasingly used as an aphrodisiac. Nevertheless there is no clinical evidence that it has sexual desire boosting effect, although increased ability to attain an erection may be interpreted as increased sexual arousal by users of these drugs.

Pulmonary hypertension
Sildenafil is also effective in the rare disease pulmonary arterial hypertension. It relaxes the arterial wall, leading to decreased pulmonary arterial pressure. This in turn reduces the load of the right ventricle of the heart and improves symptoms of right-sided heart failure. Because PDE-5 is primarily distributed within the arterial wall smooth muscle of the lungs and penis, sildenafil acts selectively in both these areas without inducing vasodilation in other areas of the body. Pfizer submitted an additional registration for sildenafil to the FDA, and sildenafil was approved for this indication in June 2005. The preparation is named Revatio, to avoid confusion with Viagra, and the 20 milligram tablets are white and round. Sildenafil joins bosentan and prostacyclin-based therapies for this condition.

Dosage
The drug is in sold in 3 dosages(25, 50, and 100 mg). It is very important to keep to the dosage of the medecine. For erectile dysfunction it is 25 mg to 100 mg taken once per day between 30 minutes and 4 hours before sexual intercourse.It is recommended to start with the 50 mg one and then, depending on the further state of the patient to lower or raise the dosage. The dosage for pulmonary arterial hypertension is one 20 mg tablet three times a day.The pills intended for erectile dysfunction are blue and diamond-shaped with the words "Pfizer" engraved on one side, and "VGR xx" on the other. The pills intended for pulmonary arterial hypertension are white, round, with "RVT 20" engraved on one side and "Pfizer" on the other.The cost of Viagra is about 10$ per pill.
Market structureIn 2000 Vagra sales made 90% of all erectile dysfunction fighting medecines in the world.By 2007 sales plunged due to appearance of multitude fakes and made 50% only.
Use in sports Professional sports players have been using drugs such as Viagra believe that the widening of their blood vessels will enrich their muscles, therefore enhancing their performance.

 
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